Effect of exercise training on HDL subclasses and cholesterol transfers to HDL in elderly individuals

Abstract Introduction Lifestyle habits play a crucial role on coronary artery disease (CAD) prevention. Exercise training promotes increase of HDL-C and decrease plasma triglycerides is an important tool against atherogenesis. determination evaluates only partially the HDL status anti-atherosclerotic potential. A number other parameters also relates metabolism function with CAD, such as subclass distribution cholesterol transfer to HDL, that have been reported impaired in CAD. It known exercise can improve those young individuals, but it has not explored whether this effect be obtained elderly subjects undergoing moderate training. Purpose Investigate effects regular practice subclasses compared subjects. Methods 111 healthy were enrolled study, divided four groups paired by sex: active (AE, n=25), inactive (IE, n=21), (AY, n=40) (IY, n=25). All performed cardiopulmonary test determine VO2 peak answered questionnaire about practice; practicing for at least one year selected 2 “active” groups. Blood samples collected lipid apolipoprotein profile. Lipid subfractions measured using Lipoprint system. Cholesterol was incubating donor lipoprotein-like nanoparticle containing radioactively labeled unesterified (UC) esterified (EC), followed chemical precipitation radioactive count. Results Data are shown Table 1. Higher both confirmed effectiveness higher AE AY than IE IY; apo A-I IY, equal. UC EC Large subfraction The intermediate IE. Comparing AY, no differences EC, well observed. Conclusion Training had ability remarkable that, despite their lower peak, group transfers profile similar group. Those results confirm features elderly. Funding Acknowledgement Type funding sources: Foundation. Main source(s): Fundação de Amparo à Pesquisa do Estado São Paulo